More from Ujwala Gaikwad Balte

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DASA ARV, , , , It is the branch of medical, science which deals with, dose of drug which is, administered to patient to get, desired pharmacological, action.

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FACTORS AFFECTING DOSE AND ACTION OF, DRUG., , ]. Age, , 2, Sex, , 3, Weight, , 4, Route of administration, , 9. Time & frequency of drug administration., 6, , ], , §, , , , . Environmental factors, . Emotional factors, . Presence of disease, 9. Accumulation, 10. Additive effect, 1], Synergism, 12. Antagonism, 13. Idiosynorasy, 14, Tolerance, 19. Tachyphylaxis, 16. metabolic disturbances

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Ahhh, , Factors Influencing Dose, » Age:, The pharmacokinetics of many drugs changes with, age., Newborn infants (pediatric) are abnormally, sensitive to certain drugs because of the immature, state of their hepatic and renal function by which, drugs are inactivated and eliminated from the, body. Failure to detoxify and eliminate drugs, results in their accumulation in the tissues to a, toxic level., Whereas, elderly patients are more sensitive to, some drug effect e.g. hypnotics which may, , Bmaioduce confusion state in them.

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Sex, , -Women do not always respond to the action of, drug inthe same manner as it done in men,, Special care snould be taken when drugs are, administered during menstruation, pregnancy, lactation., , The strong purgtive eq, Ales shouldbe avoided, during menstruation,, , Silly. the drugs which may stimulate. the, Uterine smooth muscles e.g, drastic purgatie, , animlaal drugs, ergot alkaloids are. cont, indicated during pregnancy,, , -Akohol, barbiturate, narcotic drugs ats on fetus, through placenta, , -Duting lactation, morphine, tetrayclne avoided, horauc its affect nn hahies