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Chapter -2, , PHARMACEUTICAL, INCOMPATIBILITIES

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INCOMPATIBILITY:, Incompatibility occurs as a result of, mixing two or more antagonistic substances &, an undesirable product is formed which may affect the, safety, efficacy & appearance of the pharmaceutical, preparation, , *

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PHYSICAL INCOMPATIBILITY, , When two or more substance, mixed together, a physical change takes place and an, undesirable product is formed., , Types of Physical Incompatibility:, 1.Immiscibility., 2.Insolubility., 3.Precipitation., 4.Liquefication.

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PHYSICAL INCOMPATIBILITIES:, 1. Immiscibility:-Immiscibility of two or more liquids, 2. Insolubility:-insolubility of prescribed agents in vehicle, , 3. Precipitation:-It occurs due to solvent is insoluble when it is, added to solution, , 4. Liquefaction:-Liquefaction of solids mixed in a dry state., , immiscibility:-Immiscibility of two or more liquids, , a When two ingredients are combined resulting in a, non- homogenous product, such ingredients are called, immiscible to each other and the phenomenon is, called immiscibility., , a This manifestation appears clearly in emulsions,, creams, lotions, some types of ointments., , co Oils and water are immiscible with each other which shows, physical incompatibility, , Rx, Castor oil — 15 ml, Water — 60 ml, , Prepare and dispense Castor oil emulsion, oc Causes: -In this prescription castor oil is immiscible with water, due to high interfacial tensions, which is a sign of incompatibility., , a Remedy: To overcome this type of incompatibility, emulsification is necessary with the help of emulsifying agent., , Rx, Castor oil — 15 ml, Gum Acacia - 3.75 gm, Water — 60 ml