Page 1 :
11.., nb to, aguib, Chapter, Drugs Acting ON A.N.S., (A) ADRENERGIC DRUGS AND ADRENOLYTICS, The part of the nervous system which controls the activities of the involuntary, organs in the body like heart, blood vessels, bronchioles, smooth muscles, etc. is, known as autonomous nervous system, which consists of two divisions viz., sympathetic and parasympathetic., Peripherally, the adrenergic nerves are post ganglionic fibres of sympathetic, nervous system except those innervated to sweat and salivary glands. The, neurotransmitter secreted at the nerve ending is nor-epinephrine (and to lesser, extent, epinephrine)., Scanned by TapScanner

Page 3 :
and describe them along with structures. (S. 04), alkylamine are called catecholamines, e.g. adrenaline, nor-adrenaline,, Catecholamines: The drugs which contain catechol nucleus with, e. What are catecholamines? Name any two catecholamines, are called catecholamines, e.g., adrenaline, nor-adrenaline,, isoprenaline., 6., но, 4, Catechol (3,4-dihydroxy phenyl), 3 2, но, 1. ADRENALINE/EPINEPHRINE (S. 98, 00, 01, 02, 08;, W. 96, 99, 00, 02), 3, 1 2, HO, 4, CH-CH, NH-CH,, 1., OH, 1, 6., Но, 1 (3,4-dihydroxyphenyl) 2-methyl amino ethanol, Properties, It is white or creamy white microcrystalline powder., • It is odourless and bitter in taste., It is very slightly soluble in water but practically insoluble in, alcohol., • It is levorotatory., Stability and Storage, It darkens on exposure to light and air. Hence it is stored in tightly, closed light-resistant container., Uses, It is used:, • In the treatment of bronchial asthma., • To treat heart block., • To treat acute allergic conditions., * To control superficial haemorrhage of nose and throat., • With local anaesthetic to prolong local anaesthetic effect., Scanned by TapScanner, 2.

Page 4 :
92 Pharmaceutical Chemistry II, Offcial Preparations, •Adrenaline tartarate injection., • Adrenaline eyedrops/solutions., • Adrenaline and atropine spray., • Zinc sulphate and adrenaline eyedrops BP., • Adrenaline bitartarate IP., Brand Names, Adrenar, Nor-drin., 2. ISOPRENALINE (ISO-ADRENALINE) (S. 98, 00, 02), 6., CH,, 1 2, но, 4, CH-CH, NH-CH, 1., OH, CH,, но, 1 (3,4-dihydroxy phenyl) 2-isopropylamino ethanol, Properties, • It is white crystalline powder., • It is odourless and has a bitter and astringent taste., • It is freely soluble in water., • It gives intense green colour with ferric chloride solution., Stability and Storage, It gradually darkens on exposure to air and light, Hence it is stored in, tightly closed light-resistant container., Uses, It is used:, •In the treatment of bronchial asthma., •In the treatment of heart block., •In the treatment of bradycardia., Official Preparations, • Isoprenaline hydrochloride injection., • Isoprenaline aerosol inhalation., • Slow release isoprenaline tablet., Isoprenaline sulphate IP, BP., Scanned by TapScanner, 2.

Page 5 :
Drugs Acting on ANS 93, Brand Name, Asthalin., 03. Write a note on 1. phenylephrine, 2. salbutamol., 1. PHENYLEPHRINE, Properties, It is a white crystalline powder., It is odourless and has bitter taste., • It is freely soluble in water., Stability and Storage, It is stored in tightly closed light-resistant containers., Uses, It is used:, •In bronchial asthma., • In heart block, mydriatic., Locally in nasal congestion., Preparations, Phenylephrine injection., Phenylephrine eyedrops., Brand Name, Biomydrin., Scanned by TapScanner