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INTRODUCTION:, •, , Acute post-streptococcal GN, though uncommon and sporadic in, , the Western countries, is a common form of GN in developing, countries, mostly affecting children between 2 to 14 years of, age but 10% cases are seen in adults above 40 years of age., •, , The onset of disease is generally sudden after 1-2 weeks of, streptococcal infection, most frequently of the throat (e.g., , streptococcal pharyngitis) and sometimes of the skin (e.g., streptococcal impetigo).

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ETIOPATHOGENESIS:, , , The relationship between streptococcal infection and this form, of GN is now well established., , , , Particularly nephritogenic are types 12,4,1 and Red Lake of, group A β-haemolytic streptococci (compare the etiologic, agent with that of RHD)., , , , The glomerular lesions appear to result from deposition of, immune complexes in the glomeruli.

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The evidences cited in support are as under:, 1) There is epidemiological evidence of preceding streptococcal, , sore throat or skin infection about 1-2 weeks prior to the, attack., , 2) The latent period between streptococcal infection and onset, of clinical manifestations of the disease is compatible with the, period required for building up of antibodies., 3) Streptococcal infection may be identified by culture or may, be inferred from elevated titres of antibodies against, , streptococcal antigens. These include the following;