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tastę. It is soluble in water, very soluble in alcohol but very slightly soluble in ether,, It occurs as a fine, white crystalline powder. It is odourless and has a slight bitter, rhematoid arthritis, nephrotic syndrome, systemic lupus erythematosus and tissue, 2. It is also used as immunosuppressive agent to reduce disease activity in, Antineoplastic Drug, 9.5, Concise Organic Pharmaceutical Chemistry-II, 3. CYCLOPHASPHAMIDE, Physical properties:, It occurs as a fine, white crystalline powder. It is odourless and has a sliehs, Its 2% solution has a pH between 4 and 6., Chemical properties:, 1. When its aqueous solution is boiled with silver nitrate solution, a whis, precipitate is obtained., 2. It is oxidised in liver (microsomal oxidation) to give phosphoramide mustard, with the loss of acrolein., Stability and storage:, It is discoloured on exposure to light and is unstable at temperature above 30°C., Hence, it is stored in tightly-closed, light-resistant containers., Uses :, 1. It is an antineoplastic agent used to treat:, (a) Malignant lymphomas, (b) Lymphoblastic leukaemia, (c) Myeloma, (d) Breast cancer', (e) Cancer of ovary, (f) Lung cancer (small cell type), (g) Neuroblastoma, (h) Ewing's sarcoma., (i) Hodkin's disease., immune disorder., Pharmaceutical formulations:, (i) Cyclophosphamide tablets, (ii) Cyclophosphamide injection., Brand names : Cycloxan, Endoxan Asta., Scanned by TapScanner
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Concise Organic Pharmaceutical Chemistry - IH, 9.6, Antineoplastic, 4. BUSULPHAN, It, vey, Physical properties:, 11, It is a white crystalline powder and is odourless. It is slightly soluble in w, soluble in acetone., Chemical properties:, (i) When it is heated with sodium hydroxide solution, it gives an int, characteristic pyridine-like odour., (i) It alkylates cysteine residue in protein., Stability and storage :, It is affected by air and light and hence it is stored in tightly-closed,, resistant containers., Uses :, It is a cytotoxic agent. It is used to treat:, (i) chronic granulocytic leukaemia, (ii) chronic myeloid leukaemia, (iii) polycythaemia vera, (iv) essential thrombocythaemia, (v) myelosclerosis., Pharmaceutical formulation : Busulphan tablets., Brand names : Busalfan, Myelosam, Myeleukon., Scanned by TapScanner
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Brand names : Biotrexate, Neotrexate., MERCAPTOPURINE (6-MERCAPTOPURINE), Physical properties:, It is a yellow crystalline powder and is odourless. It is very slightly soluble in, water but soluble in solutions of alkali hydroxides., Chemical properties:, (i) When its saturated alcoholic solution is treated with alcoholic mercuric, acetate solution, a white precipitate is obtained., (ii) When its alcoholic solution is warmed with alcoholic lead acetate solution,, a yellow precipitate is obtained., Scanned by TapScanner
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It is affected by air and ight and hence it is stored in tightly-closed, light, Antineoplastic Druge, Cenclee Organic Pharmaceutical Chemistry-# .9, Stabiliity and storage:, resistant containers., Uses:, 1. It is a cytotoxic agent and used to treat:, (1) Acute lymphatic leukaemia, (H) Acute myelogenous leukaemia, (Hi) Chronic granulocytic leukaemia, 2. It is also an immunosuppressive agent and used to treat nephrotic syndrome, autoimmune diseases like haemolytic anaemia, severe rheumatoid arthritis, systemic lupus erythematosus., 3. In conjunction with folic acid antagonists, it is used to treat choriocarcinoma., Scanned by TapScanner
