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Chronotherapy is a behavioral technique, in which bedtime is systematically, delayed, which follows the natural, , tendency of human biology. 24. Bedtime, is delayed by 3-hour increments each, day, establishing a 27-hour day.

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In chronotherapy, an attempt is made to move, bedtime and rising time later and later each, day, around the clock, until a person is, sleeping on a normal schedule." This, treatment can be used by people with delayed, sleep phase disorder (DSWPD), who generally, cannot reset their circadian rhythm by moving, their bedtime and rising time earlier. DSWPD, is a circadian rhythm sleep disorder,, characterised by a mismatch between a, person's internal biological clock and societal, norms. [2] Chronotherapy uses the human, phase response to light or melatonin. The, American Academy of Sleep Medicine has, recommended chronotherapy for the, treatment of circadian rhythm and sleep, disorders., , Scannee d with CamScanner

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Cnronotnerapy in cancer, Chronotherapy is the delivery of a, treatment at a specific time in attempt to, optimize therapeutic effectiveness based, on the time within the circadian cycle., The beneficial effect may be related to, the delivery of specific time cue, such as, light, food, activity or melatonin at a, specific time to modulate the circadian, rhythm, or delivery of a drug or therapy, in relationship to the circadian rhythm., The latter relies on the knowledge that, the circadian rhythm influences multiple, aspect of drug therapy from absorption,, distribution, target expression, drug, metabolism, additional mechanisms of, drug resistance, and drug elimination all, may be influenced by circadian, components. Specific timing of the, administration of a drug may influence, the more favorably the drug availability,, enhance the desired therapeutic effect or, , Scannee d with CamScanner

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decrease the likelihood of adverse side, effects (known as chronotoxicity)., Chronotherapy has been used in a variety, of diseases, such as asthma, peptic ulcer, disease, and hypertension, with varying, , success (Smolensky et al., 2016).