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12:40 © 999 Yeo “481! wil 94% Ca), , ( @slideshare.net/Prash @ :, , Databases, , 7. Primary Databases + They contains, biomolecular data in its original form. +, Experimental results are submitted directly into, the database by researchers, and the data are, essentially archival in nature. * Once a database, accession no. is given to an kind of data in, primary database then that data can’t be, changed further. * Examples : GenBank, EMBL,, DDBJ for DNA/RNA sequences. SWISS — PROT, and PIR for protein sequeces., , 8. GenBank ° It is a database from NCBI,, includes sequences from publically available, resources. * GenBank is the genetic sequence, database , an annoted collection of all, publically available DNA sequences. * GenBank, is the part of the International Nucleotide, Sequence Database Collaboration., , 9. EMBL + European Molecular Biological, Laboratory. It is an Nucleic acid Database that, comes under EBI ( European Bioinformatics, Institute). * It was Established in collaboration, with DDBJ and GenBank. « EBI’s Sequence, Retreival system (SRS) is a network browser fo, databanks in molecular biology, integrating and, linking the main nucleotide and protein, , = O Q, , Scanned with CamScanner

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databases., , 10. DDBJ » The DNA Data Bank of Japan is a, biological database that collects DNA, Sequences. ° It is located at the National, Institute of Genetics in the Shizuoka Prefectu, of Japan. « It is also a member of the, International Nucleotide Sequence Database, Collaboration or INSDC., , 11. SWISS - PROT + SWISS — PROT is a curate, protein sequence database which strives to, provide a high level of annotation ( such as, description of the function of proteins , Its, domains structure , post translational, modifications , variants , etc.) * SWISS - PRO”, was Created in 1986 by Amos Bairoch with, Swiss Institute of Bioinformatics ., , 12. PIR * The Protein Information Resources, (PIR) is an integrated public resource of prote, informatics that supports genomic and, proteomic research and scientific discovery. «, PIR maintains the Protein Sequence Database, (PSD), an annoted protein database containin, over 283000 sequences covering the entire, taxonomic range., , Scannee d with CamScanner

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13. Secondary Database = It contains Data, derived from results of analysed primary data. :, The data in secondary database is either, manually created or generated automatically. +, It contains some valuable information such as, about mutations or evolutionary relationship., 14. PROSITE * PROSITE is a protein database. I, consist of entries describing the protein, families , domains and functional sites as well, as amino acid patterns and profiles in them. °, They are manually curated by a team of the, Swiss Institute of Bioinformatics and tightly, integrated into Swiss prot protein annotation., 15. pfam + Pfam is a database of protein, families that includes their annotations and, multiple alignments generated using hidden, markov models. * The general purpose of the, pfam database is to provide a complete and, accurate classification of protein families and, domains., , 16. Some Structural database + PDB ( protein, data bank): Comprises of : 1. PDBe ( PDB of, Europe) 2. PDBj ( PDB of Japan ) * SCOPE:, Structural classification of protein * CATH:, Class Archeitecture Topology Homology « They, all contains information generated from XCrystallgraphy and NMR Experiments., , Scanned with CamScanner