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Sulphonamides 17, , 09, State structure, chemical name, uses, preparations of, sulphadiadine,, , SULPHADIAZINE 0, 97, 00, 02, 05, 07; W, 96, 01, 06), ', , /' 8, , . . \, , J 80, NH ON yf, 4 8 Nm", , 2 (P-aming benzene sulphonamide) pyrimidine, , , , Properties, * His a white crystalline powder,, , * fis practically insoluble in water,, + Sis soluble in solutions of alkali hydroxides and carbonates., , + fis slightly alkaline in taste,, , Morage, , li should be stored in a well tightly closed container and protected, from light,, , Uses, , Sulphadiazine is used in the treatment of:, , * Meningitis + In burns, * Urinary tract infection * Toxoplasmosis., Preparations, , Sulphadiazine tablet IP, BP., Sulphadiazine sodium injection BP., Marketed Names, , Vysimol, Adiazine,, , O4, Write a note on sulphonamide which Is a derivative of, guanidine,, , , , SULPHAGUANIDING (8, 96, 99, 03, 095; W, 98, 01), , NH, , , , );-80;—NK—C—~ NH,, , 4 2, N (P-amino benzene sulphony|) guanidine, , Scanned with CamScanner
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try Il, 18 pharmacoutical Chem! ry alan, , Properties dle-shaped crystals,, , as White, nee, egg, LASICTESS., , y soluble in water, , ’ on exposure to light., , e ll occurs, , © Itis odourl, + Tris sparing, It darkens slowly, , Storage inet and, I tightly closed container and protected from lie, , It is stored in Wwe |, , Uses oo, ae, at intestinal infections like bacillary dysentery, , © Iris used to tre’ al SORES, + Iris used in urinary tract infections., , Preparation, Sulphaguanidine tablet IP., , Q5. Write a note on sulphonamide used in eye infection,, SULPHACETAMIDE (S. 00, 01, 04, 05, 07, 09; W. 01, 02, 08), , 5 6, , HN SO,NH ——COCH,, , 342, N-acetyl sulphanilamide, , Properties, * It occurs as a white crystalline powder., , * Itis soluble in water and alcohol., , * Aqueous solutions are acidic to litmus., , * It has a saline taste., , Storage, , It should be stored in well closed light resistant containers., Uses, , * It is used to treat eye infections,, , * It is used to treat urinary tract infections,, Preparations, , * Sulphacetamide eyedrops., , * Sulphacetamide eye ointment., * Sulphacetamide tablet,, , Scanned with CamScanner
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Sulphonamides 19, , Hrand Naties, Albueid, Sulaniyad, , Q.6, What ls co-trimoxazole? Give ita Importance, usea, official,, preparation and brand names, OA Write a note on co-trimoxazole, , COPTRIMONAZOLE (8, 97, 0, OS; W.00, 01, 05, 06, 08), , Co-tiimoxavole is a mixture of 4 party Of sulphamethoxazole and |, partot Gaimethoprin,, , The fwo components of co-trimoxazole interfere with the bacterial, ayathests of tetrahydrofolic acid which is an essential stage in the, production of nucleic acids,, , Sulphamethoxazole inhibits the synthesis of dihydrofolic acid from, PABA and trimethoprim inhibits the action of dihydrofolate reductase, and prevents the synthesis of tetrahydrofolic acid from dihydrofolic, acid, , , , Sulphamethoxazole, , * tis a sulphanilamide derivative,, * Itis a white crystalline powder,, , * Itis odourless and has bitter taste,, * Itis very slightly soluble in water., , Trimethoprim, , * Iisa pyrimidine derivative., , * It is a white to yellowish powder., * Jtis odourless and has bitter taste,, * Itis very slightly soluble in water,, , When sulphamethoxazole is given alone, a resistance develops to, susceptible bacteria and needs higher doses,, , ‘Trimethoprim also develops resistance when given alone. When, combination of these two drugs is used, the spectrum of antibacterial, activity is increased,, , This is due to synergistic effect,, , , , , , Uses of Co-trimoxazole, , Wis used in:, , * Urinary tract infections,, , Respiratory tract infections like bronchitis, pneumonia,, * Meningitis,, , * Enteric infections like typhoid and paratyphoid., , Scanned with CamScanner
