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Aromatic Waters, , , , , , , , , , ¢ Chloroform water © Cinnamon water, , © Concentrated Cinnamon wator ¢ Camphor wator, , © Concentrated Dill water * Concontrated Anise water, , © Peppormint wator © Chloroform doublo strength water, , © Concentrated peppermint wator, , , , , , , , Aromatic waters are clear, saturated aqueous solutions of volatile oils or contain other, fromatic or volatile substances, also known as medicated waters, Taste_and odors of, aromatic waters are similar to the drugs or volatile substances from which they are, prepared. Aromatic waters should be free from smoky conditions and-should_be_free, , from unpleasant odors. Generally aromati a are used as a flavoring agent, solvent,, , , , perfumed vehicles or as a pharmaceutical aid {All substance used in the preparation of, aromatic waters should be of pharmacopoeia quality. If the aromatic waters are nonofficial then it should have best quality of flavoring agents. ,, , Two official methods are commonly used for the preparation of aromatic waters e.g., , 1. Solution Method ; ; ; ;, 2. Distillation Method - (3) Allow Bie LA el sie beet, , 1. (a) Solution Method (without using distributing agent) : Aromatic waters may be, prepared by repeatedly shaking 0.2% V/V or 0.2% W/V of volatile substance’ with, purified water, Keep it aside for 12 hours and make up the volume upto 100 ml by, adding sufficient purified water after filtration. ¢.g. chloroform water, camphor water, etc si, , Scanned with CamScanner

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2 Practical Pharmaceutics, , Advantages, , —1) Minimum chemicals are required, 2 No need of any specific equipment, , ~% Less time consuming, , 4 More economic, , , , , , , , ot, , Disadvantages, , 1. Light and air may deteriorate volatile oils. &, , 2 Uniform distribution ofdrug may not be possible. A\ er \ r, (z wo wackhod J, UGANS, , 1. (b) Solution Method (using distributing agetits) © Aromatic waters may be prepared, by thoroughly shaking the volatileolls.wvith 15% of powdered tale or with a sufficient, wantity of kiesetgubt « fi ith half quantity of purified water, The, quantity of Kieselguhr or pulped filter papers with half quantity of purified water, The, mixture is agitated for ten to fifteen minutes by wrist action shaker or by hand. This, \sater is then filtered through the wetted filter papers and volume of the aromatic water, , is adjusted by the distilled water through the same filter papers., , , , , , , , , , , , Advantages, , , , 1 Oils or other substances are subdivided by this method, , Finally divided oils rapidly dissolves and gives saturated solution, Repeated shaking of aromatic water is not required, , 4 Time required is less then other method, , Excess oil drops are coalesce which facilitated that filtration of aromatic water, o-Itis more economic, , , , , , , , , , dvantages, , 1. Itneeds more additives, 2 Itis not suitable to all types of aromatic waters, 3. Some times it fails to distribute oils in aqueous part, e.g. Dill water. Peppermint water, Cinnamon water, Anise water, , 1. (c) Solution method (with solubilising agents) | Some of the aromatic water are, prepared by using solubili agents such as polysorbate-20 or tween-20 but this, method is not convenient because these materials (solubilising agents) are susceptible to, moulds growth and in higher concentration (more than 2.0%) impart an objectionable, gily taste., , , , Aromatic Waters 3, , ey Distillation Method : Distillation method for the preparation of aromatic water is the, ancient method. Different authorities give different direction for the preparation of, “womatie water by the distillation method [Drug distillate ratios for fresh drugs, for dried, drugs such as cinnamon, anise Dill, Fennel and Caraway, and for dried leaf such as, peppermint are 12 of 2:1, 1:10 and 3.10 respectively Various types of distillation, apparatus are used in the distillation process but for the preparation of aromatic waters, mainly metallic distillation apparatus is used. Some times steam still is also preferred., {Drug material is reduced in small size and added small quantity of purified water} In this, process excess of oil substance is removed and, if-necessary, the clear water portion is, filtered. The distillate is retumed several times to the still with fresh portion of the, flowers or other material and, used for double distillation, triple distillation quadruple, distilled. This process is called cohabation e.g. rose water etc., , , , , , , , Advantages, , , , |. Oil is mixed homogeneously or saturated with water easily., iis suitable for all types of material, , 3. Maximum oil extracted from the plants, A Wis fast process., . > It is more economic., , Di, , , , , , , , vantages, , |. Oil gets evaporation by heat., 2. Some unpleasant empyreumatic odor is produced., 3 Iisa complicated process., , , , INCOMPABILITY, , Most of the aromatic water containing preparations are incompatible because it is easy to, salt-out by the addition of some salts. If aromatic water is used as a vehicle then it may, be replaced by distilled water. The salting out action of aromatic water by the action of, soluble salts may be used in the evaluation of aromatic waters. This evaluation is based, , on the amount of standard sodium citrate solution required to produce cloudiness in, aromatic water., , , , PRESERVATION, No preservatives should be added in the aromatic water or medicated waters. If these, , products are become cloudy or get deteriorated, these products are not suitable to use, and should be discarded., , Scanned with CamScanner

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4 Practical Pharmaceutics, CONTAINERS, , 1 Use small mouth amber colored glass bottle (50 ml — 500 ml) for packing, 4 meal, 2 Plastic container, screw capped white or colored bottle or may also be used mets {, containers. small mouth screw capped containers, , 3 Containers should be airtight and light resistant, , STORAGE, , Product (containers) should be well protected from the light and excessive heat, LABEL, , Label should have following information about the product, , a Quantity and name of product | ., , Composition Ingredients should be indicated in term of percent or in suitable I, forms (or each § ml contains), , Manufacturers name (Mfg. by), , Date of manufacturing (Date of Mfg.), , Expiry Date (ifany), , Batch no and storage condition, , Mention dose and other special remarks such as warming or cautions etc. where, , required as mentioned in official books or for maintenance of efficacy of the, , product ¢ 2, , ce, , a6, , FOR INTERNAL USE ONLY _ \, , , , , , FOR EXTERNAL USE ONLY, , [PROTECT FROM LIGHT, , STORE IN DRY AND COOL PLACE, , , , SHAKE WELL BEFORE USE, , , , , , SHOULD ;, _OUDY OR FOREIGN PARTICLES. \, , , , , , , , Hote Product should be discarded if they become cloudy or contain any foreign matter by any reason such as, ctenoration, volatihzation, decomposition or mald growth, , Aromatic Waters 5, EXERCISE NO. 1, Object : To prepare Chloroform water, , Requirements Chloroform, purified water, etc, Theory Chloroform (trichloromethane), is clear, odorless and a mobile liquid with, ethereal odor and has burning sweet taste! Specific gravity of chloroform is between, 1474 10 1478 Care should be taken in handling chloroform because in presence of, Mame os light it produces harmful gases like hydrogen chloride and phosgene gas. The, small amount of ethanol in chloroform retards the formation of carbonyl chloride, (CoCl:)] tis rarely used as an inhalation anesthetic due to its serious side effect on heart, and liver Internally in small dose it is used as carminative and extemally as irritant, In, the preparation of chloroform water, vigorous shaking is necessary to sub-divide the, chloroform in sinall globules to enhance the solubility. In this preparation distributive, agent is not required, as the product is only half saturated with chloroform., , , , , , Formula, , Chloroform 0.25 ml, , , , Purified nt to produce 100.0 ml, , Procedure, , |, Measure the required amount of chloroform and dissolve it in purified water by, vigorous shaking., , 2. Chloroform is completely dissolved in water., , 3. Transfer in clean amber color container and close it tightly., , , , Category = Pharmaceutical aid (, Dose :15 to 30 ml, , Stor, , , , : Store in a well closed container and protected from light., Ises : Pharmaceutical aid, preservative, vehicle and general anaesthetic., , VIVA VOCE QUESTIONS, , 1, What is the use of chloroform water?, , 2. Why chloroform is not used as an anaesthetic agent?, , 3. How to avoid formation of phosgene gas in chloroform?, 4, Why ethanol is used in this preparation?, , f E, , Scanned with CamScanner