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Reg. No., , Question Paper Code : X10190, B.E./B.Tech. DEGREE EXAMINATIONS – NOV / DEC 2020, Seventh Semester, Biotechnology, BT8023 Tissue Engineering, (Regulation 2017), , Time: 3 Hours, , Answer ALL Questions, , Max. Marks 100, , PART- A (10 x 2 = 20 Marks), 1., , Define tissue engineering, , 2., , State Tissue Engineering Triad, , 3., , Identify the physical factors influencing ceil migration on engineered tissue, , 4., , State the major difference between fetal and adult wound healing, , 5., , Name any two synthetic polymers that are biodegradable, , 6., , Name the biomaterial that substitutes for the natural lens, , 7., , Differentiate cancer cells from stem cells, , 8., , State the difference between pleuripotent stem cells and hematopoietic cells, , 9., , Name two clinically successful organogenesis project, , 10. State the difference between gene therapy and tissue engineering on the aspect of clinical, , application, PART- B (5 x 13 = 65 Marks), , 11., , 12., , 13., , 14., , a), , Discuss the critical role of ECM in tissue engineering, OR, b) Enumerate the recent challenges on using cells as therapeutic agents, , 13, , a), , Write short notes on tissue types with suitable diagram, OR, b) Outline the intracellular and intercellular interactions essential for engineered, tissue, , 13, , a), , 13, , Enumerate on the biological properties of biomaterials in tissue engineering, OR, b) Write short notes on scaffold fabrication technologies and also comment on, its advantages and disadvantages., a), , Elaborate on the technological and ethical significance of using tissue, derived stem cells, , 13, , 13, , 13, , 13

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OR, b) Detail on the characteristic features of a specific type of stem cells referred to, as biological gold, 15., , a), , Elaborate on treatment of skin ulcers with a suitable diagram, Write a short notes on orthopedic application of tissue engineering, OR, b) Discuss on the ethical issues associated with the clinical implication of tissue, engineered products, Write short note on any one successful clinical application of tissue, engineering, , 13, , 7, 6, 8, 5, , PART- C (1 x 15 = 15 Marks), 16., , a), , VEGF mediated angiogenesis is a powerful tool in tissue engineering. Justify, the statement with substantial evidence and examples., OR, b) Stem cell therapy has become a promising mode of treating various diseases., Discuss the advantages of stem cell therapy over other mode of treatments., , 15, , 15