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Chapter 16, , Molecular Basis of Inheritance, , Which one is incorrect with re, as, features of human genome ? Péct to salient, , (1) Total number of genes js @pproximately 30,000, (2) More than 2% of genome codes for Proteins, , (3) Repeated sequences form major Part of human, genome, , (4) SNP, occupy about 1.4 million locations, , In an eukaryotic m-RNA molecule, 2.4 million, bases are found. The fumber of phosphodiester, bonds and hydrogen bonds Present in it is, , (1) 2.4 million, 7 million, (2) 2.4 million -1, 7 million, (3) 2.4 million-1, zero, , (4) 2.4 million, 7.2 million, , In §*174 virus 5386 nucleotides are found. Find the, number of glycosidic bonds and phosphodiester, , bonds in this, (1) 5386, 5385, (3) 5385, 5385, , Read the statements carefully and choose the, Correct option with respect to one strand of DNA, , (a) Phosphate moiety in the 5’ end gives acidic nature, to nucleotide, , (b) 3° end of polynucleotide chain contains free 3’—, OH group, , (c) Nitrogenous bases are projected outside of the, helices, , (d) Phosphate moiety is projected at, and pentose is projectad towards ou, , strand, (1) Both a and b are correct, (2) ¢ and d are correct, (3) b and c are correct, (4) Only d is correct, , (2) 5386, 5386, (4) 5385, 5386, , , , 5., , 10., , Find the incorrect match, , (1) Nucleoside - basic in nature, , (2) Purines glycosidic - bond at 1’-9 position, , (3) Pyrimidines - nitrogen at 1, 3 position, , (4) Uracil has -CH, in 5° position, , Which one cannot be used in DNA fingerprinting ?, (1) Saliva (2) Sperm, , (3) RBC (4) Bone, , Recognition sequence for transcription in, prokaryotes is, , (1) TATATAT (2) TATAAT, (3) TATAAAT (4) CAAT, , In Griffith's experiment heat killed S-11 strain, transfers ___ to living R-II strain to make it, , , , (1) RNA, virulent, (2) DNA, harmless, , (3) Some transforming principle, virulent, (4) DNA, rough walled, , Which character of RNA does not make it a genetic, material ?, , {1) Monocisfronic, , (2) Autocatalyticin nature, (3) High rate of nutation, (4) Polycistronic, , Heavy DNA sediments at bottom during CsCI, density gradient centrifugation as the density of, CsCl is, , (1) Highest at the top, (2) Highest at the bottom, (3) Lowest at the bottom, (4) More than one option is correct

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PF 120 Molecular Basis of Inheritance, , 11. How many enzymes are involved in DNA replication, in eukaryotic nucleus as given in the box ?, , , , ligase, DNA pol - tll, DNA pol - |,, , , , Topoisomerase, Helicase, Primase,, , , , , , Gyrase, (1) § (2) 4, (3) 7 (4) 3, 12, Which RNA polymerase plays role in synthesis of, 5s rRNA?, (1) RNA polymerase-1 (2) RNA polymerase-II, , (3) RNA polymerase-Ill_ (4) Both (1) and (3), 13. Genes are monocistronic in eukaryotes but these, , genes are called split genes, because, , (1) Only exons apear in processed m-RNA, (2) Exons of same gene are located at different loci, , (3) Exons are intervened by introns, , (4) Introns do not appear in matured m-RNA, 14. Overlapping of codons present in genome of, , (1) Virus, (3) Animal, , 15. Split-gene arrangement can be seen in, (1) Eukaryotic gene, (3) Viral gene, , (2) Plant, , (1) 5° end of new strand, , (2) 3’ end of new strand, , (3) 5° end of coding strand, (4) 3’ end of template strand, , 17. Gene regulation in eukaryotes may occur at all of, , the given except, , (1) Formation of primary transcript level, (2) Splicing level, , (3) Translational level, , (4) Replication level, , 18. Sequencing of DNA of non-human organisms can, , help solving challenges in, (1) Health care, , (2) Energy production, (3) Bioremediation, , (4) All of these, , (4) All of these, , (2) Prokaryotic gene, (4) Both (2) and (3), , 16. During DNA and RNA synthesis, a nucleotide is, always attached to the newly formed strand at, , , , 19., , 20., , 21., , 22., , 23., , 24., , 25., , Catalyst Package foe, , cDNA is, , (1) Complementary DNA, , (2) Generated from mRNA, , (3) A form of DNA, , (4) More than one option is correct, Find the incorrect entry from the box, , , , Organism | Genetic material Number oft,, (1)]O% 174 dsDNA 5386 bp, , , , , , (2) |-phage dsDNA 48502 bp, (3)| E. coli dsDNA 4.6 «10 by, (4) pel dsDNA 3.3 * 10°bp, , , , , , , , , , In which case the Tm value of DNA is highes: 2, (1) DNA with 10% cytosine, (2) DNA with 20% cytosine, (3) DNA with 30% guanine, (4) DNA with 40% cytosine, , In a linear DNA molecule of 100 bp, 30% is, guanine. Find the total number of hydrogen bands, and phosphodiester bonds in that DNA, , (1) 200, 200, , (2) 260, 198, , (3) 240, 200, , (4) 300, 200, , Adenine differs from cytosine in having, , (1) 9 membered ring, , (2) Amino group, , (3) Heterocyclic structure, , (4) 6-membered ring, , Translation process is always, , (1) Dictated by RNA and represented by RNA, (2) Dictated by DNA and represented by ONA, (3) Dictated by DNA and represented by RNA, (4) Dictated by RNA and represented by ONA, , E.coli has 4,6 x 10® base pairs in DNA. Find, length of E. coli DNA, , (1) 4.6 mm, (2) 3.56 mm, (3) 1.36 mm, (4) 1.26 mm, , aie

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7) Catalyst Package tor nee, , i. 26. The super coiling of DNA in E.coli cell is maintained, by _ and the super coiled DNA is called, , —, , (1) Histone beads, prochromosome, (2) Protamines, Genophore, , (3} Polyamines, Genophore, , (4) Protamines, Nucleoid, , 27, Which of the following is correct with respect to, search for genetic material 7, , (1) Transforming principle — S-IIl and R-ll strains of, Diplococcus, , (2) Bacteriophage DNA - Labelled with P22, (3) Transduring phage — Transduction, (4) More than one option is correct, , 28, Read the statements carefully and choose the, correct option with respect to DNA replication, , (1) Lagging strand has polarity of 3° - 5° direction, (2) Leading strand has polarity of 5’ + 3’ direction, (3) DNA replication is semiconservative, , (4) Whole genome of eukaryotes is replicated, whthin 38 minutes, , 29. There are of DNA polymerase in E.coli, while in human cell., (1) 1 type, 3 types (2) 3 types, 5 types, (3) 3 types , 3 types (4) 5 types, 5 types, , 30. DNA duplication in E.cofi takes 20 minutes. An, E.coli cell with heavy DNA is allowed to grow in N™*, , containing NH,CI for 100 minutes. Find the ratio of, Hybrid DNA molecule to light DNA molecules after, , , , , , 100 minutes., (1) 1:31 (2) 1:15, (3) 1:3 (4) 1:1, , 31. Unzipping of DNA helices in replication fork is, possible due to the activity of, (1) Topoisomerase-l (2) Topoisomerase-ll, (3) Helicase (4) Gyrase, , 32, If antisense strand of DNA with 3° — 5° polarity has, the following sequence, find the base sequence in, , MRNA E.coli, Ss 7, 5, v < Antisense, Strand, " x, Sek c, , , , , , (1) 5S'UAC CCG ACG AUC3’, (2) 3'UAG CGU CGG GUAS’, , , , 33., , 35,, , 37., , Molecular Basis of Inhertance 12), (3) S‘AUG GGC UGC UAG3’, (4) S'GAU CGU CGG GUAY, A transcription unit in prokaryotes usually contains:, , (1) Structural genes flanked by promoter in upstream, and terminator in downstream, , , , (2) Structural genes flanked by terminator in, upstream and promoter in Cownstream, , (3) Structural genes flanked by @ promoter in, upstream and an enhancer in downstream, , (4) Structural genes flanked by @ receptor gene in, upstream and a promoter in downstream, , Match the columns and choose the correct option, with respect to RNA polymerase activities, , Column-1 Column-ll, (A) 5.8S rRNA (i) RNA pol-tt, (B) 5S rRNA (ii) RNA poll, (C) hnRNA (iii) RNA pot-lll, , (1) Ati), Bi), Coil (2) Ai), B(iil), Cf), (3) Aili), BOll), Ci) (4) Adi), Bf), C(ii), , Read the statements carefully and choose the, correct option with respect to tailing of hnRNA, , (A) Tailing is Gone prior to splicing, , (B) Poly-A polymerase adds 200-300 adenylate, residues at 3’ end of hnRNA, , (C) Tailing is template independent process, , (D) Tailing proceeds G-cap formation, , (1) Both A and B are correct, , (2) Both B and C are correct, , (3) Both C and D are correct, , (4) A, B and C are correct, , 3’ end of tRNA forms which bond with amino acid?, (1) H-bond (2) Ester bond, , (3) Peptide bond (4) Disulphide bond, , Which of the followings are associated with, eukaryotes 7, , (A) Pribnow box (B) Hagness box, (C) CAAT box ({D) Split gene, (1) A and B (2) Band C, , (3) A, C and D (4) B, C and O, Which codon has no tRNA ?, , (1) AUG (2) UUG, , (3) UAG (4) GAG

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"422 Molecular Basis of Inheritance, , 39. Which statement is correct for application of, Wobble hypothesis to tRNA ?, , (1) tRNA is soluble RNA, , (2) 60 types of tRNA are found in cytoplasm, , (3) Provides economy in number of tRNA at the time, of translation, , (4) tRNA has anticodon, 40. Which gene in lac operon is a constitutive gene ?, (1) i-gene, (2) a-gene, (3) z-gene, (4) y-gene, Which feature of DNA used during DNA, fingerprinting ?, (1) Stability, (2) Helical structure of DNA, (3) Slow rate of mutation, (4) DNA polymorphism, , 42. Sense strand of DNA has -GAG- in normal case. If, it is mutated to -GTG-, which amino acid will be, , incorporated in the polypeptide 7, (1) Glutamic acid (2) Valine, (3) Glycine (4) Aspartic acid, , , , 4., , 43. Which codon is without exception with respect to, degeneracy ?, (1) GUG (2) UAA, (3) UGG (4) AAG, , 44. Which eukaryotic rRNA is not formed by RNA, polymerase | ?, (1) 28S (2) 18S, (3) 5.8S (4) 5S, , 45. Read the statements carefully and choose the, incorrect option with respect to repressible system., , (1) It is mostly in switched on condition, (2) Regulated by feed back inhibition, (3) Controls catabolic process, , (4) Aporepressor is inactive, , 46, Which bacteriophage has dsDNA as genetic, material ?, , (1) 0 * 174, (2) Lambda (2) phage, , (3) TMV, , (4) More than one option is correct, , 47., , 48., , 49., , 50., , 51., , 52., , , , 53., , 54., , ~, , Cats! Package for Nery, , Which one is not true wrt function of RNA 2, (1) May carry genetic code, , (2) Acts as a catalyst, , (3) May act as an adapter molecule, , (4) Replication, Which of the following is constant for all Species >, , A+G, , ore 1, , (1) Size of DNA Toc, , (3) Length of DNA only (4) Both 1 and 2, Read the statements carefully and choose thy, , correct option, , (a) 5 methyl uracil is a base in DNA, , (b) Cytidine is the nucleotide in both RNA and Dna, {c) Purines are 6 membered compounds, , (d) Both purines and pyrimidines are homocyciic, compounds, , (1) a and b are correct (2) b and c are correct, , (3) c and d are correct (4) Only a is correct, , In which case daughter DNA is not identical t, , parent DNA ?, , (1) Pallindromic DNA = (2): ss Circular DNA, , (3) ds linear DNA (4) B- DNA, , If pitch of B-DNA is 3.4nm, how many base pairs, , will be found within 34nm ?, , (1) 110 bp (2) 100 bp, , (3) 93 bp (4) 80 bp, , Most stable type of RNA is, , (1) tRNA, , (2) tRNA, , (3) MRNA, , (4) snRNA, , Capping of m-RNA is related to, , (1) GUG, , (2) Soluble RNS, , (3) 5m uracil |, (4) S'm Guanosine triphosphate, , Which of the following is Kornberg enzyme ?, (1) DNA-pol-Iil, , (2) RNA pol - 1, , (3) DNA pol - tI, , (4) DNA pol - | , (2)

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for NEET, , , , , killed $-Il! strain changes living R-II strain cells, "into virulent form by a process called, , (1) Transcription, , (2) Reverse transcription, , Q) Transformation, , (4) Transtation, , 55, Find the odd one out with respect to genetic, material, , (1) TMV (2) QB phage, , (3) o * 174 (4) HIV, , 57, Match the columns and choose the correct option, with respect to non proteinous enzymes, , Column | Column I, (a) Ribonuclease-P (i) Peptide bond, formation, , (b) Sn-RNPs (ii) Cleavage in the larger, precursor RNA, (Primary transcript), (c) 28S-rRNA (iii) Splicing, , (1) afi), b(ii), efiii) (2) alii), b(ili), c(i), (3) aii), bi), (iil) (4) afi), bfi), C(ii), , . Which enzyme removes RNA primer from okazaki, fragments in prokaryotes 7?, , (1) DNA pol - & (2) DNA pot -1, (3) DNA ligase (4) DNA pol - f, , . Which enzyme has no work in replication fork with, respect to DNA synthesis 7, , | (1) DNA pol (2) DNA pol-Itt, (3) Gyrase (4) DNA pol-il, 50. Which figure is correct with respect to DNA, , teplication in replication fork ?, , 5 3 3 5, , (4), , , , , , 61., , 62., , 63., , 65., , 66., , 67., , Molecular Basis of Inheritance ares, Which of the following DNA strand has the aetna., Sequence as that of the newly synthesized RNA 9, , (1) Template strand (2) Coding strand, , (3) Non coding strand (4) Antisense strand, Transcription and translation in Prokaryotes occur in, , (1) Two compartments, , (2) One compartment, , (3) Nucleus and cytoplasm, , (4) Nucleoplasm and cytosol, , shows the reminiscent of antiquity and, fepresents the dominance of RNA word, , (1) Exons, translation (2) Introns, Splicing, (3) Introns, Transcription (4) Exons, Splicing, , Genetic code shows the inter-relationship of all of, the given except, , (1) Nucleotide sequence in DNA, , (2) Nucleotide sequence in mRNA, , (3) Amino acid sequence in polypeptide chain, (4) Nucleoside sequence in DNA, , Who got the experimental proof of double helical, structure of DNA?, , (1) Watson, (2) Wilkins, (3) Rosalind Franklin, (4) Both (2) and (3), , Why DNA is better to store genetic information as, compared to RNA?, , (1) Helical structure of DNA, (2) Undergoes slow mutation, (3) Structurally stable, , (4) Both (2) and (3), , Unwinding of double helix of DNA is catalysed by, helicase and is dependent upon, , (1) ATP, , (2) GTP, , (3) CTP, , (4) TTP, , Which two loops of t-RNA have same number of, unpaired bases?, , (1) DHU and anticondon loop, (2) Anticodon and TC loop, (3) Anticodon and variable loop, (4) DHU and TYC loop