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cd, , 9., , “vill. PHARMACEUTICAL CHEMISTRY, (ORGANIC), , , , , , 1. Basic Reaction Mechanism, Isomers, , , , , , Which of the following rule is not used to determine the electronic configuration 2, , (a) Pauli’s -b) Saytzeft (c) Hund’s (d) Aufbau, All statements are true for SN, reaction, except:, , (a) follow first order kinetic (b) rearrangement is possible, , s10n of Contiguration takes place (d) two step reaction, All statements are true for E, reaction, except:, , a) follow first order kinetic (b) reactivity order 3° > 2° > 1° o, (c) always B-hydrogen attracted (d) single step reaction, Orientation of elimination reaction follows, (a) Markonikov’s rule, (c) Michael addition (d) Hoffman rule, Which one is polar aprotic solvent 2, (b) Ethanol (c) Water (d) All, Which one is weakest bond ?, (a) Co-ordinate (b) Covalent (c) H bond id) Van der wall, Compound A is highly volatile and insoluble in water, so bonding in A is, (a) co-ordinate (b) ionic bond, , uc) covalent — (d) polar covalent bond, , Diel’s Alder comes under, , a) cycloaddition reaction (b) electrocyclic, , , , (c) sigmatropic fd) all, Dichloro carbine as an intermediate is generated in .... reaction., (a) Wittig {by Aldol, , (c) Hoffman (d) Reimer Tiemann, , 10. Which statement is true for crossed condensation ?, , (a) both aldehyde/ketone having a o-hydrogen, , (©) it does not having a-hydrogen, ud) all, , nnn ay, , Scanned with CamScanner
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11. Which one is homogeneous catalyst ?, (a) Ni (b) Pt, (o) Pa ud) Wilkinson catalyst, formation of 1° amine with one carbon less ? i, , 12. Which reaction involves the, (a) Baeyer-Villiger rearrangement, , (b) Pinacol-Pinacolone rearrangement, , (c) Beckmann rearrangement, , 13. Racemic mixture is.........., (b) 1:10, , (c) 1:50 mixture of laevo and dextro form (d) none, , 14, Laevocetrizine is......., (a) R form: (b) S form, (c) Z form (d) E form of cetrizine, 15. Which form is more stable ?, (c) both (d) none, , (a) cis (b) trans”, 16. Absolute configuration is named on the basis of, (a) atomic weight (b) atomic number —, , (c) mass number (d) charge of the group, , 17. Adrenaline is more active in .........., , (a) laevo (b) dextro, , 18. Geometrical isomerism occurs due to, , (c) both (d) none, , (b) due to the asymmetric centre, , (b) both (d) none, 19. Geometrical isomerism is seen in, (a) alkene (b) cyclic compound, , (©) both — (d) none, , 20. Which isoforms of phthalidomide may cause phocomelia ?, , (a) R form (b) S form (c) Both (d) None, , 21. An organic compound has 42 1% C, i and 6.49 ight i ts, ee © © and 6.4% H. Its molecular weight is 342, (a) C3H,O, (b) C,H,O, 4) CyHy,0,, (d) none, , ‘2, 0.177 monobasic acid requi, ‘moi quired 30 ml of N i - complet, neutralization. Its molecular weight will be abdieobintetoalcmal, , (a) 49, Mb) 59 (c) 69 (d) 79, , Scanned with CamScanner
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23, An organic compound (A) contains C = 76.6% and H = 6.38%. It is soluble in, - < eenelh ; ; . ed -3 8%., aqueous sodium hy droxide solution and gives Violet colour with FeCl,. Its alkaline, g S rs a, , solution on being heated with CCl, gave an acid (B) of equivalent weight 138, Identify A. ‘, , a) C;H;OH (b) CH,OH () CH;OCH, id) GJHSOH, , Homolytic fission of covalent bond between carbon atoms will produce, (a) wo carbonium ions ., , (b) two molecules, vec) free radicals - (d) carbonium ion and carbanion, _. The order of stability of carbonium ions is, , 25, EEE ED (b) 3°> 195 2° (c) 12> 2°> 3° (d) 1°>3°>2°, , 26. Which of the following carbonium ions Will be most stable 2, , (a) CH (b) CH;CH: (c) (CH;)CH” (CH= CHCH3, , 27. Which of the following statement is Correct regarding nucleophile ?, (a) They leave an overall positive charge., , ub) They have a lone pair of electrons., , (0) They have an unpaired electrons., (d) They have empty orbitals., 28, Which of the following is a lewis acid ?, , JA) AICI; (b) CH;OH () NH; (d)CH,OCH,, , 29, Which of the following ranges best represents the strength of a hydrogen bond ?, , De, , (b) 60-80 kCal_ —(c) 80-100 kCal (d) 100-120 kCal, 30. Which alkyl free radical is the most stable ?, (a) methyl (b) primary (c) secondary, , 31. How many isomers are possible for the compound with molecular formula CyHg ?, , la) 2 b (b) 4 See (d)8, , 32. Which compound is not an isomer of the other three ?, (a) n-pentane (b) 2,2-dimethylpropane, , ; (c) 2-methy! butane (d) 2,2-dimethylbutane, 3. Alkenes show geometrical isomerism due to, {®) asymmetry, , )) rotation around a single bond, (0 resonance, , 4 wp:, , , , , geometrical isomerism ¢, (b) 2-methyl-2-pentene, _ (d) 2-methyl-2-butene, , g compounds exhibit, , Scanned with CamScanner
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35, , 36., , 37, , 38, , , , , . Amolecule is said to be chiral, , (a) if it contains plane of symmetry, (b) if it contains centre of symmetry, ed on its mirror image, , (d) if it can be superimpos, , . It is possible to distinguish between optical isomers, (b) by mass spectrometry, , (a) by using chemical test, , (c) by IR spectroscopy, , . Ameso compound:, (a) is an achiral molecule which contains chiral carbons, , (b) contains a plane of symmetry or a centre of symmetry, ~ (c) is optically inactive, - A molecule contains n number of asymmetry centres, possible isomer for the moje, , is, 7 2, (b) 2n oe id) ns2, , (a) n, Meso-tartaric acid is:, , 39., (a) sometimes optically active (b) always optically active, (c) sometimes optically inactive (d) always optically inactive, 40. How many optical isomers are possible for lactic acid ?, 4 . * (c) 6 (d) 8, . Consider (R) and (S) - i si istingui, compounds? (S) - butanol. Which physical property distinguishes the ts, a) melti i, ( elting point (b) solubility in common solvent, (d) IR spect, 42. Which one is more acidic ? _, (b) trans (co) b, . oth, 43. Which one is more stable form ? -_, (a) cis form, the Whichaore | (b) trans (c) both (d) none, ab = is more stable form of conformation ?, oat form, 45. Whi : : (b) chair form (c) both, 5. Which one is having more melting point form ? is none, ——— (b) irae form (c) both (d) none, Villiger ii migration of group from carbon to nitrogen ?, trangement (b) Pinacol-Pinacolone rearrangeme™, , , , , (d) Benzilic acid rearrangement, , Scanned with CamScanner
